Top latest Five ceesdekker.net Urban news
Top latest Five ceesdekker.net Urban news
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Working with solitary-molecule optical and AFM imaging and power-spectroscopy techniques, we request to unravel the mechanistic areas of the construction and dynamics of chromosomes. Our study pursuits include things like:
Human Rad51 filaments on double- and single-stranded DNA: correlating standard and irregular sorts with recombination perform.
[Laughs] ‘It was certainly an excellent danger! At the time, I had been perfectly knowledgeable that it could go Erroneous Which I could develop into a lot less productive, but I just dismissed that. Curiosity has usually been my strongest driving drive. And fortunately all of it worked out.’
Non-equilibrium folding of particular person DNA molecules recaptured nearly a thousand occasions in a stable point out nanopore
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Microbiology has only been around for any century, considering that we began to review micro-organisms extra very seriously. I assumed nanobiology was an appropriate phrase, due to the fact all molecular biological appropriate interactions happen with the nanoscale: a protein is a number of nanometres in dimensions, DNA is two nm thick.’
All parameters were being exactly the same for each panel On this movie, aside from the Original placement of the 6hb rod (shown in blue) within the nanopore. Simulations that terminated early on account of translocation with the rod in the pore are marked by a gray background.
2011, 1st in vitro measurements of transport across a single biomimetic nuclear pore complex; enhancement of multiplexed magnetic tweezers for kilo-molecule experiments; and fixed the system of homology recognition in DNA homologous recombination
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Bulk-surface coupling identifies the mechanistic connection among Min-protein designs in vivo As cees dekker well as in vitro
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‘That issues the artificial mobile, as Portion of the Dutch BaSyC initiative. Craig Venter appeared leading-down in All those days and recognized about 5 hundred genes that are minimally essential for a working mobile. We wish to seem base-up: how do we transfer from the couple molecules to a complete biological process?
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It was an extremely attention-grabbing time, throughout which I gained a lot of help from Delft College of Technological know-how, in which I used to be a professor at some time, And that i started numerous collaborations with molecular biologists. That aided me master a great deal.’